Research provides better understanding into how genes make us prone to allergies pennmedicine ImmunityCP
DNA interactions within the genomic segment encompassing the ETS1"We discovered that these interactions, work like a dimmer switch," said Vahedi."When there are changes in the DNA in this area, it can mess up the dimmer switch, causing problems with controlling the ETS1 protein. This can lead to imbalances in our immune cells and cause allergic inflammations.
Instead, they may be caused by small changes in the DNA that affect how genes work together. However, researchers still do not know much about how these changes in DNA relate to how our genes are organized or how they affect how genes are expressed in most complex diseases. "This work demonstrates how small differences in our DNA can disturb the balance between our immune cells, resulting in significant observable characteristics in patients. This phenomenon may occur in other common diseases such as autoimmune disorders," said Henao-Mejia.
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