Study reveals a mechanism behind multisystem inflammatory syndrome in children (MIS-C).
University of California - San FranciscoAug 7 2024 Study reveals a mechanism behind multisystem inflammatory syndrome in children .
The researchers found that the children's immune systems had latched onto a part of the coronavirus that closely resembles a protein found in the heart, lungs, kidneys, brain, skin, eyes and GI tract, and launched a catastrophic attack on their own tissues. COVID's unexpected consequence in kids As the novel coronavirus spread among millions of people, MIS-C cases mounted, affecting about 1 in 2,000 children under 18 with COVID.
Co-senior author Mark Anderson, MD, PhD, who directs the Diabetes Center at UCSF, suggested Bodansky try a tool that he and Joe DeRisi, PhD, president of Chan Zuckerberg Biohub San Francisco, were using, called Phage Immunoprecipitation Sequencing , to see if it could uncover the cause of MIS-C. PhIP-Seq revealed that one third of the MIS-C cases had autoantibodies for an obscure human protein, called SNX8, which is present in certain immune cells that reside throughout the body. For some reason, the immune system was making antibodies targeting itself.
The T-cell caper The match between the autoantibodies, SNX8 and the N protein was a clear sign of an autoimmune overreaction.
Autoantibodies Autoimmune Disease Blood Brain Cell Children Coronavirus Covid-19 Critical Care Diabetes Heart Hospital Immune System Lungs Multiple Sclerosis Pandemic Pediatrics Protein Research SARS SARS-Cov-2 Sclerosis Skin Syndrome Type 1 Diabetes Virus
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