Recent research from the University of Helsinki sheds new light on the behavior of the KRAS gene in two of the deadliest cancers—pancreatic and colorectal cancer.
Helsingin yliopisto Oct 21 2024 These findings suggest potential pathways for targeted therapies in KRAS-driven cancers.
Published in Cancer Research and Nature Communications, the studies demonstrate that the loss of the normal version of the KRAS gene can accelerate the growth of pancreatic and colorectal cancers. Interestingly, these tumors seem less likely to metastasize. The results also suggest that when a patient's pancreatic cancer loses the normal KRAS gene, the cancer becomes more sensitive to a type of drug called MEK inhibitors. This means that patients with specific genetic profiles—those who have lost the normal KRAS gene—may be more likely to benefit from targeted therapies that can slow tumour growth.
Colorectal Colorectal Cancer Genetic Gene Research
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