Researcher contextualizes a study on IgG4 anti-Spike levels after repeated SARS-CoV-2 mRNA vaccination ScienceMagazine ragoninstitute antibody antibodies spike mRNA vaccine SARSCoV2 COVID19 coronavirus covid
By Neha MathurFeb 9 2023Reviewed by Danielle Ellis, B.Sc. In a recent focus piece published in Science Immunology, a researcher emphasized the need to reconsider messenger ribonucleic acid coronavirus disease 2019 vaccination strategies in the future.
In addition, these researchers showed that an arginine at 409 amino acid position in the CH3 domain of IgG4 impeded CH3:CH3 pairing, facilitating its dissociation into two half molecules comprising one heavy and an associated light chain. These two half-molecules pair to form bispecific IgG4 antibodies by a process called “Fab arm exchange.” In vivo, this occurs in endosomes during FcRn-mediated recycling.
Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Similarly, prolonged activation of recently described CD4+ helper T cells aids the differentiation of the interleukin 10 -expressing extrafollicular helper T cells, which then drives IgG4 class switching. Interestingly, this cell type also collaborated with reactivated B cells that had switched to other IgG subtypes.
Conclusions To conclude, it was not feasible to precisely decipher the negative consequences of increased IgG4 levels, if any, post-repeated vaccination with mRNA COVID-19 vaccines. Yet, in light of these findings, there is an urgent need to reconsider the relevance of COVID-19 vaccination for public health.
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