Symptomatic SARS-CoV-2 infection during pregnancy increases risk of complications for mother and infant SapienzaRoma SARSCoV2 COVID19 Pregancy Complications
By Neha MathurFeb 7 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the International Journal of Environmental Research and Public Health, researchers investigate the obstetric and neonatal outcomes in pregnant females infected with the severe acute respiratory syndrome coronavirus 2 who did not receive a coronavirus disease 2019 vaccine.
Despite the numerous studies that have described the pathophysiology of SARS-CoV-2 infection during pregnancy, there remains a lack of data on the consequences of the coronavirus disease 2019 in the mother and her neonate, as well as the risk of vertical transmission. Post-delivery, neonatal nasopharyngeal swabs, as well as amniotic fluid, cord blood, and placenta tissue samples were collected. Cord blood samples were subsequently tested for antibodies against the SARS-CoV-2 spike and nucleocapsid proteins, as well as the presence of SARS-CoV-2 ribonucleic acid , whereas placental tissue samples were used for histological evaluation.
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy SARS-CoV-2-positive pregnant women had fewer chronic diseases than controls at a rate of 14.71% and 17.91%, respectively. However, 44.12% of SARS-CoV-2-infected pregnant women reported pregnancy-associated complications as compared to 18.38% of controls.
Vaginal swabs and amniotic fluid samples were negative for SARS-CoV-2 infection. However, SARS-CoV-2 RNA was detected in 4.4% of maternal samples, 2.9% of umbilical cord blood samples, and 1.5% of placental tissue samples, thus indicating that vertical transmission is rare. Neonates born to both symptomatic and asymptomatic mothers had comparable anti-S and anti-N antibody levels in their cord blood.
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