Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation ScienceMagazine UninaIT obesity immunity immuneregulation overnutrition nutrition health
By Bhavana KunkalikarApr 3 2023Reviewed by Danielle Ellis, B.Sc. In a recent perspective published in Science, researchers explored the correlation between autoimmunity and obesity.
Type 1 diabetes susceptibility and obesity Obesity has been identified as a risk factor for autoimmune disorders, including type 1 diabetes as well as multiple sclerosis . Studies conducted on young obese individuals have revealed a heightened likelihood of developing MS during young adulthood and adolescence with a 1.6- to 1.9-fold elevation in risk. However, this correlation with obesity was not observed at the onset of MS.
The overexpression of nutrients and leptin leads to constant mTOR activation in T cells, resulting in the irregular signaling of T cell receptors . Excessive mTOR activation within T cells imitates a potent, above-normal T cell receptor stimulation that does not allow forkhead-box P3 gene transcription. The expression of this gene is crucial for the initiation and preservation of anti-inflammatory CD4+CD25+FOXP3+ regulatory T cells .
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Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulationResearcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation ScienceMagazine UninaIT obesity immunity immuneregulation overnutrition nutrition health
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