Biopsies are clinical tools commonly used to diagnose a variety of diseases or to monitor tissue for abnormal growth or even rejection of a transplant.
Vanderbilt UniversityJul 17 2024 During biopsies, tissue samples are removed from the body so they can be examined more closely, but depending on the type of tissue that's needed, the procedure can be rather invasive.
The "EV" in EV Fingerprinting stands for extracellular vesicles, which are membrane-bound particles that contain biologically active cargo and that contribute to cell-cell communication in health and disease. Although EVs have been observed since at least the 1980s, their origin and purpose have not been clearly defined.
"Fingerprinting allows you to characterize EVs with minimal sample preparation in a high-throughput manner, and allows you to better classify the types of vesicles in the sample," von Lersner said. Related StoriesEV Fingerprinting constitutes an unprecedented advancement toward the characterization of EVs because it can analyze the composition of the lipid bilayers of the EVs in a sample and breaks the sample down into individual EV populations, which previous bulk analysis methods could not do. Using the composition of the lipid bilayers to separate EV populations is a novel approach that capitalizes on an EV characteristic that had been previously overlooked by the field.
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