Researchers at the RIKEN Cluster for Pioneering Research (CPR) have developed technology that can alter, within the body, the recognized identity of proteins. The innovation, published in Nature Communications on October 2, allowed researchers to target mouse tumors with a protein and then transport that protein out of the body.
RIKENOct 3 2024 Researchers at the RIKEN Cluster for Pioneering Research have developed technology that can alter, within the body, the recognized identity of proteins. The innovation, published in Nature Communications on October 2, allowed researchers to target mouse tumors with a protein and then transport that protein out of the body. This means that cancer-killing drugs could be sent directly to tumors and then excreted from the body after dropping off their payload.
In a previous study, Tanaka's team examined cancer-targeting capabilities of different identification-marking molecules -; called glycans -; that they attached to albumin. They found that identification pattern 'A' could bind to human colon cancer, as well as be transported to the bladder for excretion in urine, while identification pattern 'B' caused albumin to be picked up by the liver, sent to the intestines, and excreted from there.
In the first proof-of-concept experiment in the mouse body, they labeled albumin-1 with a fluorescent protein and then injected it into the mouse blood stream with or without the switcher. As predicted, when injecting albumin-1 with the switcher, researchers observed fluorescence in the intestines, similar to what they observed after injecting albumin-2. Without the switcher, fluorescence was only seen in the blood, bladder, and urine.
Bladder Blood Cancer Colon CPR Drug Delivery Drugs Fluorescence Protein Research Technology Tumor
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