Researchers explore disease severity post-infection with SARS-CoV-2 Omicron in hematologic patients

United Kingdom News News

Researchers explore disease severity post-infection with SARS-CoV-2 Omicron in hematologic patients
United Kingdom Latest News,United Kingdom Headlines
  • 📰 NewsMedical
  • ⏱ Reading Time:
  • 32 sec. here
  • 2 min. at publisher
  • 📊 Quality Score:
  • News: 16%
  • Publisher: 71%

Researchers explore disease severity post-infection with SARS-CoV-2 Omicron in hematologic patients unidue SARSCoV2 COVID19 Coronavirus Omicron Variant HematologicPatients

By Dr. Priyom Bose, Ph.D.Jun 29 2022Reviewed by Aimee Molineux Patients with hematologic disease are at an elevated risk of morbidity and mortality post-infection with the severe acute respiratory syndrome coronavirus 2 virus. It is currently unknown whether the Omicron variant leads to reduced disease severity in such individuals.

The disease has now been seen to affect multiple systems including the cardiovascular system, the nervous system, and the gastrointestinal tract. The Omicron variant is currently the dominantly circulating strain of SARS-CoV-2 and its clinical presentation differs markedly from prior variants. Although the mortality rate has decreased, Omicron has a reduced susceptibility to be neutralized by treatment with monoclonal antibodies or vaccination. Since the data on hematologic patients with COVID-19 is rare, in the current study, scientists analyzed the disease characteristics in this extremely vulnerable population.

We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

NewsMedical /  🏆 19. in UK

United Kingdom Latest News, United Kingdom Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatmentResearchers analyze potential of niclosamide as a SARS-CoV-2 treatmentA recent study posted to the bioRxiv* preprint server assessed whether niclosamide could be employed in coronavirus disease 2019 (COVID-19) therapy.
Read more »

Scientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parametersScientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parametersScientists conduct meta-analysis of the impact of SARS-CoV-2 on sperm parameters SARSCoV2 COVID19 Fertility MaleFertility
Read more »

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants - Nature CommunicationsA global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants - Nature CommunicationsHere, Farley et al. perform untargeted lipidomics to assess how SARS-CoV-2 rewires host lipid metabolism. SARS-CoV-2 viral proteins specifically induce lipid droplet formation and dramatically change lipid metabolism to support infection; interfering with lipid metabolism using small molecule inhibitors decreases virus production.
Read more »

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillanceRecombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillanceIn a recent article posted to the bioRxiv* preprint server, researchers at Texas Biomedical Research Institute, Georgia State University, and the University of Alabama at Birmingham developed a bireporter-expressing recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) for tracking SARS-CoV-2 infection.
Read more »

Differential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing MiceDifferential Pathogenesis of SARS-CoV-2 Variants of Concern in Human ACE2-Expressing MiceSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current pandemic, resulting in millions of deaths worldwide. Increasingly contagious variants of concern (VoC) have fueled recurring global infection waves. A major question is the relative severity of the disease caused by previous and currently circulating variants of SARS-CoV-2. In this study, we evaluated the pathogenesis of SARS-CoV-2 variants in human ACE-2-expressing (K18-hACE2) mice. Eight-week-old K18-hACE2 mice were inoculated intranasally with a representative virus from the original B.1 lineage or from the emerging B.1.1.7 (alpha), B.1.351 (beta), B.1.617.2 (delta), or B.1.1.529 (omicron) lineages. We also infected a group of mice with the mouse-adapted SARS-CoV-2 (MA10). Our results demonstrate that B.1.1.7, B.1.351 and B.1.617.2 viruses are significantly more lethal than the B.1 strain in K18-hACE2 mice. Infection with the B.1.1.7, B.1.351, and B.1.617.2 variants resulted in significantly higher virus titers in the lungs and brain of mice compared with the B.1 virus. Interestingly, mice infected with the B.1.1.529 variant exhibited less severe clinical signs and a high survival rate. We found that B.1.1.529 replication was significantly lower in the lungs and brain of infected mice in comparison with other VoC. The transcription levels of cytokines and chemokines in the lungs of B.1- and B.1.1.529-infected mice were significantly less when compared with those challenged with other VoC. Together, our data provide insights into the pathogenesis of previous and circulating SARS-CoV-2 VoC in mice.
Read more »

Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort studyViral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort studyAbstractBackground. In January 2022, United States guidelines shifted to recommend isolation for 5 days from symptom onset, followed by 5 days of mask wearing.
Read more »



Render Time: 2025-02-23 22:53:58