The study uncovers gene expression signatures that predict neonatal sepsis, highlighting the potential for early intervention to reduce mortality in infants.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMOct 31 2024 Study reveals gene expression changes at birth that could enable early detection and treatment of neonatal sepsis.
Neonatal sepsis, affecting infants in their first 28 days, occurs in 2-3 per 100 live births globally, particularly impacting preterm and low-birth-weight neonates. Mortality rates can reach 17.6%, especially in low/middle-income countries, with sepsis being a leading cause of neonatal death. Related StoriesBlood samples were processed for Ribonucleic Acid sequencing, and bioinformatic analyses were conducted using R. Differentially expressed genes were identified using Differential Gene Expression Analysis based on the Negative Binomial Distribution , comparing healthy controls, localized infection cases, and septic neonates.
Transcriptional differences were evident in septic neonates even before clinical symptoms emerged. Among the neonates with DOL 0 samples who later developed sepsis, a total of 469 DEGs were identified when compared to healthy neonates and 476 DEGs in relation to those with localized infections.
Sepsis Blood Diagnostic Gene Expression Heat Inflammation Machine Learning Mortality Protein
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