Most people don't enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA (mRNA), that can be sprayed and inhaled.
American Chemical SocietyNov 14 2024 Most people don't enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA , that can be sprayed and inhaled. A study in the Journal of the American Chemical Society reports steps toward making inhalable mRNA medicines a possibility.
mRNA medicines encode proteins that could treat or prevent a variety of illnesses, including lung diseases. However, these proteins are delicate and can't enter cells by themselves. To get intact mRNA inside lung cells, tiny fatty spheres can be used like suitcases to store and transport the components until they reach their final destination.
Now, Daniel Anderson, Allen Jiang, Sushil Lathwal and colleagues have hypothesized that a different type of polymer, one with repeating units of positively and negatively charged components called a zwitterionic polymer, could create mRNA-containing lipid nanoparticles that can withstand nebulization .
Related StoriesThen in animal trials, the researchers determined that a lower-cholesterol version of the lipid nanoparticles with zwitterionic polymers was the optimal formulation for aerosol delivery. When transporting an mRNA encoding a luminescent protein, this nanoparticle produced the highest luminescence within the animals' lungs and a uniform protein expression in the tissues, thereby demonstrating that it had the best ability to deliver inhaled mRNA.
Cystic Fibrosis Fibrosis Lungs Nanoparticle Nanoparticles Polymers Protein Research RNA Technology
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