The study highlights T2-low and T17-high asthma endotypes in minoritized youths, offering insights for precision medicine and improved asthma management.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMJan 7 2025 Study highlights the prevalence of T2-low and T17-high asthma endotypes among racially and ethnically minoritized youths, paving the way for precision medicine approaches.
While T helper 2 -high asthma, characterized by eosinophilic inflammation and elevated levels of interleukin -4, IL-5, and IL-13, has been extensively studied and treated with targeted therapies, less is known about T2-low endotypes, including T17-high asthma and paucigranulocytic asthma. This study, conducted from 2014 to 2017, focused on Puerto Rican youths aged 9-20 years with asthma. Participants underwent spirometry, blood tests, and nasal sampling for gene expression analysis, using methods similar to STAR.
The mean age differed, with VDKA participants being the youngest , followed by STAR and EVA-PR . Overweight or obesity was prevalent, affecting between 45.6% and 65.4% of participants, and most individuals had Medicaid or medical assistance, with 1% to 4% uninsured.
Transcriptomics Allergen Blood Children Chronic Corticosteroid Gene Gene Expression Genes Inflammation Interleukin Medicine Obesity Precision Medicine Research Respiratory Respiratory Illness RNA Spirometry
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