The global burden of inflammatory bowel diseases (IBD), primarily Crohn's disease (CD) and ulcerative colitis (UC), continues to rise. Recent data show incidence rates of up to 17.8 cases per 100,000 person-years for CD and even higher for UC, reaching 28.4 per 100,000 person-years.
Xia & He Publishing Inc.Aug 23 2024 The global burden of inflammatory bowel diseases , primarily Crohn's disease and ulcerative colitis , continues to rise. Recent data show incidence rates of up to 17.8 cases per 100,000 person-years for CD and even higher for UC, reaching 28.4 per 100,000 person-years. These diseases primarily affect older populations and vary geographically, with higher prevalence rates in highly developed countries.
Fecal Calprotectin FC is a cytosolic calcium and zinc-binding protein expressed by neutrophils and other immune cells. It is a stable protein that can persist in feces for up to a week, making it an ideal biomarker for non-invasive monitoring. FC has been extensively studied in IBD and has shown good-to-optimal correlation with endoscopic, histologic, and transmural disease activity.
Multi-target biomarkers Research has also explored the potential advantages of using multi-target tools that combine serum and fecal biomarkers with clinical activity indexes. These tools aim to enhance diagnostic and monitoring effectiveness by providing a more comprehensive picture of disease status.
Biomarker Colonoscopy C-Reactive Protein Diagnostic Gastroenterology Myeloperoxidase Protein Research Ulcerative Colitis
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