Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.
By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Sep 13 2024 Sodium in tumor microenvironments found to heighten T-cell activation, suggesting new cancer treatment avenues In a recent study published in Nature Immunology , researchers investigated the direct influence of sodium ions on the cytotoxic cluster of differentiation 8 -expressing T cells and hence on antitumor cytotoxicity.
About the study The researchers investigated the effect of sodium ion concentrations on cytotoxic T-cell activity and antitumor immunological responses. The researchers investigated the molecular pathways by which increasing extracellular sodium-chloride concentrations can convert T cell receptor engagement in cytotoxic T lymphocytes into greater activation of T cells. They expected higher extracellular sodium chloride concentrations to enhance electromotive forces for Ca2+ entry following TCR-induced calcium channel activation. They investigated NaCl-induced relative hyperpolarization of membrane potential .
Breast Cancer Cancer Cancer Treatment Cell Cell Death Cytokine Cytotoxicity Genes Immunity Immunology In Vitro In Vivo Ion Membrane Pancreatic Cancer Potassium Receptor T-Cell Tumor
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