COVID vaccination found to have lower risk of autoantibodies than naturalimmunity yale NatureComms
Antigens with an average REAP score greater than 0.5 across all samples were defined as non-specific binders and excluded from further analysis. Autoantibody reactivities were defined as antigens with REAP score >2 and >1.96 row- wiseTMPRSS2-VeroE6 kidney epithelial cells were cultured in Dulbecco’s Modified Eagle Medium supplemented with 1% sodium pyruvate and 10% fetal bovine serum at 37 °C and 5% CO. The cell line has tested negative for contamination with mycoplasma.
For the acute COVID-19 cohort and the Benaroya cohort, REAP and ELISA/neutralization studies were performed by the investigator before receiving associated clinical annotations. For the Yale HCW cohort, CoronaVac cohort, and the myocarditis cohort, the investigator received clinical annotations at the time of REAP/ELISA/neutralization studies. However, samples were analyzed in the same manner in a randomized plate layout.
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