Scientists explore immune memory of common cold coronaviruses before the SARS-CoV-2 pandemic era ljiresearch CommonCold ColdVirus SARSCoV2 COVID19 Pandemic ImmuneMemory
By Shanet Susan AlexJul 26 2022Reviewed by Aimee Molineux In a recent study published in the Cell Host and Microbe journal, researchers assessed the immune memory of common cold coronaviruses three years before the coronavirus disease 2019 pandemic.
Nevertheless, there is inadequate evidence on the prevalence of memory T cell reaction toward CCC, especially their stability with time. Comprehending the steady-state dynamics of CCC antibody and T cell reactions in people has potential significance, given the sustained SARS-CoV-2 evolution during the COVID-19 pandemic.
The team analyzed PBMC samples of 32 subjects from an observational study of Bordetella pertussis. They examined the magnitudes of CD4+ T cell reactions to CCC and other antigens over time. Moreover, immunoglobulin binding to recombinant spike receptor-binding domain antigens of CCC were examined in matched plasma samples.
While everyone showed measurable antibody titers to CCC, the team discovered that individuals' levels of T cell reactivity varied. Further, the participants most likely to be linked to pre-existing SARS-CoV-2 immunological reactivity were those with significant CCC T cell reactivity and low antibody titers.
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