Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.
By Tarun Sai LomteMay 31 2024Reviewed by Benedette Cuffari, M.Sc. A recent study published in Nature Immunology demostrates that durable asthma remission can be achieved with engineered and long-lived chimeric antigen receptor T-cell treatment in mice.
CAR T-cell therapy, for example, has cured patients with B-cell malignancies. This has led researchers to become increasingly interested in determining whether T-cells could be engineered for long-term remission of non-cancerous diseases as well. Thereafter, 5T cells were administered into mice and assessed for their conditioning-free expansion and eosinophil elimination. After one week, 5T cells were not detected in the peripheral blood and eosinophils were unaffected, thus demonstrating that 5T cells do not expand or deplete eosinophils in vivo.
To this end, 5TIF 4 cells reduced IL-5 and IL-13 levels, whereas 5TIF treatment led to slightly lower levels of IL-5 alone. Both 5TIF and 5TIF 4 cells exhibited a central memory-like phenotype. Eosinophils were also absent in the lungs and bronchoalveolar lavage fluid of treated mice and T-cell infiltration was reduced. Additionally, 5TIF 4 cells were more effective in curbing IgE and IL-13 production.
In a second chronic asthma experiment, mice received 5TIF 4, 5TIF, or PBS and were subsequently challenged with HDMs several times after a 10-week resting period to induce asthma recurrence. While both cell types reduced lung inflammation, 5TIF 4 cells were more effective.
Antigen Bronchial Hyperresponsiveness CAR T-Cell Cell Chimeric Antigen Receptor Chronic Efficacy Eosinophil Eosinophilia Immunoglobulin Immunology Inflammation Lungs Molecule Protein Receptor T-Cell
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