Small-molecule drug reverses neural effects of concussion ucsf PNASNews
that are critical to cognition. Mice treated with the drug also showed sustained improvements in working memory.
To investigate this, UCSF graduate student Elma Frias, Ph.D., began to explore how the ISR and its inhibition affected neurons in theUsing advanced imaging techniques, Frias observed the effects of TBI on dendritic spines, the primary site of excitatory communication between neurons, over the course of multiple days.formation, maturation and elimination—dynamics that support learning and memory.
These aberrant dynamics were rapidly reversed once mice were treated with ISRIB. By blocking the ISR, the drug was able to repair the neuronal structural changes resulting from the brain injury and restore normal rates of spine dynamics. These neuronal structural alterations were also associated with an improvement in performance to normal levels in a behavioral assay of working memory, which persisted for over a month after the final treatment.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Streamer breaks back in two places in foam pit stand at TwitchCon San DiegoA streamer broke her back in two places at a reportedly unsafe stand at TwitchCon San Diego. The stand, a collaboration…
Read more »
Panthers fire HC Rhule after 1-4 startThe Carolina Panthers fired coach Matt Rhule on Monday, the team announced. The Panthers are 1-4 this season, suffering their latest loss Sunday against the San Francisco 49ers at home. They went 11-27 since hiring Rhule in 2020. Assistant coach Steve Wilks has been named interim head coach. GO...
Read more »
The Mets' season is over. The magic has gone. 'It’s cruel. It really is.'The Mets' season is over. The magic has gone. After 21 seasons as a manager, Buck Showalter understands the pain better than most. 'It’s cruel,' he said. 'It really is.'
Read more »
Tomori has Chelsea reunion to forget but different story for Aubameyang in MilanAC Milan defender Fikayo Tomori was sent off against former club Chelsea as the Blues seized control of Group E with a 2-0 victory at the San Siro in the Champions League. But it was a different re…
Read more »
Small-molecule drug reverses neural effects of concussionA small molecule called ISRIB that was identified at UC San Francisco can reverse the neuronal and cognitive effects of concussion in mice weeks after an injury occurred, new research has found.
Read more »