Science, Space and Technology News 2024
UCLA researchers have discovered a new memory mechanism in the brain that reduces energy costs and enhances memory storage, potentially offering new insights into Alzheimer’s and other memory disorders.researchers have identified a process that memories while reducing metabolic costs, even during sleep.
In the world of physics, mathematical models are commonly used, from Kepler to Newton and Einstein, to reveal amazing things we have never seen or even imagined, such as the inner workings of subatomic particles and the inside of a. Mathematical models are used in brain sciences too, but their predictions are not taken as seriously as in physics. The reason is that in physics, predictions of mathematical theories are tested quantitatively, not just qualitatively.
“If we test our theory quantitatively on data in vivo, then these are just interesting mathematical games, not a solid understanding of memory-making magic,” said Mehta. Hahn and Dr. Sven Berberich, also a coauthor, measured the membrane potential of identified neurons from the entorhinal cortex in vivo, using whole cell patch clamp technique and then used anatomical techniques to identify the neuron. Simultaneously they measured the activity of the parietal cortex, a part of the neocortex that sends inputs to the entorhinal cortex.
“It’s as if a wave comes in and the entorhinal cortex said, ‘There is no wave! I’m going to remember that recently there was no wave so I am going to ignore this current wave and not respond at all’. This is persistent inactivity” Mehta said. “Alternately, persistent activity occurs when the cortical wave disappears but the entorhinal neurons remember that there was a wave very recently, and continue rolling forward.
“All this sounded too good to be true, so we really pushed our mathematical microscope to the limit, into a regime where it was not designed to work,” said Dr. Choudhary. “If the microscope was right, it would continue working perfectly even in unusual situations.”
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