Figuring out how the tissues in our bones, adrenal glands, muscle and fat 'talk' to each other could help scientists better understand what happens to our skeletons with age, when our bones tend to lose mass and become weaker, leaving us at risk for falls and fractures.
Augusta UniversityAug 1 2024 Figuring out how the tissues in our bones, adrenal glands, muscle and fat "talk" to each other could help scientists better understand what happens to our skeletons with age, when our bones tend to lose mass and become weaker, leaving us at risk for falls and fractures.
So, we made a knockout model, for the for what we thought was a key receptor that helped initiate that bone-making process. And instead of fixing the problem, it made everything worse. McGeeLawrence says. "We figured out, long story short, that there was another receptor that we had kind of overlooked that might be driving some of these problems.
MR also is a receptor for aldosterone. And for glucocorticoids, steroid hormones that are a key modulator of the body's stress response. With this new funding, McGee-Lawrence and her team want to examine local activation of glucocorticoids, which circulate through the body in inactive or active forms. "We already know that especially with aging, when MR goes up so much, the bone doesn't compensate and express a lot of the enzymes that deactivate glucocorticoids," she explains.
Aldosterone Blood Blood Pressure Bone Knockout Muscle Receptor Research Stress
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