Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular...
University of Chicago Medical CenterNov 20 2024 Cancer researchers at the University of Chicago and the University of California, San Francisco have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications that can arise from the collision of two critical cellular processes: transcription and DNA replication.
Lixing Yang, PhD, Assistant Professor in the Ben May Department of Cancer Research at the University of Chicago, in collaboration with researchers at UCSF, sought to identify tumors with high levels of TRCs to explore treatment options targeting replication, transcription and DNA damage repair. Lixing Yang, PhD, Assistant Professor in the Ben May Department of Cancer Research, University of Chicago
Related StoriesThe researchers analyzed data from 6,193 whole-genome-sequenced tumors to study TRCs' contributions to genomic instability. Structural variations in tumors resulting from collisions exhibit a unique signature, which can be detected through dosage imbalance -; a change in the number of copies at the DNA junctions, where strands of DNA join. This phenomenon occurs when extra copies of a DNA strand are mistakenly patched onto other DNA regions, causing structural variations.
One of the study's most promising findings was that cancers with large TDs are more sensitive to specific drugs, such as WEE1, CHK1 and ATR inhibitors. These drugs offer a potential treatment pathway for cancers characterized by high levels of TDs.
Cancer DNA DNA Damage DNA Replication Drugs Genes Genetic Information Genome Genomic Prostate Prostate Cancer Research Tobacco Transcription Tumor
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