A study conducted at the Center for Research on Redox Processes in Biomedicine (Redoxoma) helps understand how high blood sugar (hyperglycemia), one of the manifestations of diabetes, can cause thrombosis.
São Paulo Research Foundation Nov 6 2024 A study conducted at the Center for Research on Redox Processes in Biomedicine helps understand how high blood sugar , one of the manifestations of diabetes, can cause thrombosis. The findings, reported in an article published in the Journal of Thrombosis and Haemostasis, can contribute to the development of strategies to prevent cardiovascular dysfunction in diabetics.
The study showed that peri/epicellular protein disulfide isomerase A1 regulates platelet-endothelium interaction in hyperglycemia through adhesion-related proteins and alterations in endothelial membrane biophysics. Biochemical and biophysical modifications To investigate platelet-endothelium interaction in hyperglycemia, the researchers created a model with human umbilical vein endothelial cells cultured in different glucose concentrations to produce normoglycemic and hyperglycemic cells and assessed PDI's contribution using whole-cell PDI or pecPDI inhibitors.
The researchers then investigated whether cytoskeleton reorganization affected cell membrane stiffness, since substrate stiffness increases platelet adhesion. Using atomic force microscopy, they demonstrated that hyperglycemic cells were stiffer than normoglycemic cells.
Blood Sugar High Blood Sugar Thrombosis Biomedicine Cardiovascular Disease Cell Cytoskeleton Diabetes Dyslipidemia Education Heart Hydrogen Peroxide Hyperglycemia Medical School Membrane Platelet Platelets Protein Research
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