Study links Western diet to chronic inflammation and colorectal cancer growth

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Study links Western diet to chronic inflammation and colorectal cancer growth
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Colorectal cancer, the second leading cause of cancer-related deaths in the United States, may be fueled by the food on our plates.

University of South FloridaDec 10 2024 Research ers at the University of South Florida and Tampa General Hospital Cancer Institute have uncovered a potential link between the Western diet – dominated by ultra-processed foods and unhealthy oils – and the chronic inflammation that drives tumor growth.

According to Yeatman, the findings emphasize the urgent need to reevaluate the components of the Western diet, which typically consists of excessive consumption of added sugars, saturated fats, ultra-processed foods, chemicals and inflammatory seed oils. In previous studies, the USF Health Heart Institute found an imbalanced diet not only impacts colorectal cancer, but also plays a role in other diseases, including Alzheimer's, diabetes and cardiovascular conditions.

While the molecules are difficult to detect, Halade used a highly sensitive analytical technique to identify trace amounts of lipids in 162 tumor samples from patients at Tampa General Hospital. The tumors were frozen within 30 minutes of removal and transported to his lab via USF and TGH Cancer Institute's Biobank, in collaboration with USF Health Colorectal Surgery and the Gastrointestinal Oncology Program at TGH Cancer Institute.

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