A double-blind, randomized, placebo-controlled trial was conducted to determine whether percutaneous coronary intervention (PCI) relieves angina more than a placebo procedure in patients with stable angina who are not receiving antianginal medication. The study followed patients for 12 weeks and assessed the angina symptom score as the primary endpoint.
Percutaneous coronary intervention ( PCI ) is frequently performed to reduce the symptoms of stable angina . Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal medication remains unknown.We conducted a double-blind, randomized, placebo-controlled trial of PCI in patients with stable angina . Patients stopped all antianginal medication s and underwent a 2-week symptom assessment phase before randomization.
Patients were then randomly assigned in a 1:1 ratio to undergo PCI or a placebo procedure and were followed for 12 weeks. The primary end point was the angina symptom score, which was calculated daily on the basis of the number of angina episodes that occurred on a given day, the number of antianginal medications prescribed on that day, and clinical events, including the occurrence of unblinding owing to unacceptable angina or acute coronary syndrome or death. Scores range from 0 to 79, with higher scores indicating worse health status with respect to angin
Percutaneous Coronary Intervention PCI Stable Angina Placebo Procedure Antianginal Medication Randomized Trial Symptom Assessment Angina Symptom Score
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