A recent study in the journal BMC Medicine evaluates the real-world impact of combining antidepressants with statins in UK adults, revealing lower discontinuation rates but similar efficacy compared to antidepressant-only treatment.
By Neha MathurNov 12 2023Reviewed by Sophia Coveney In a recent study published in BMC Medicine, researchers evaluate real-world acceptability, tolerability, and efficacy of concomitant antidepressant and statin treatment using data from QResearch, a large United Kingdom primary care database.
A meta-analysis of placebo-controlled RCTs showed that concurrent statin and antidepressant use were more efficacious in participants with depression versus patients taking an antidepressant plus placebo, and this treatment markedly reduced depressive symptoms at two months. About the study In the current cohort study using observational design, researchers investigated anonymized electronic healthcare records of more than 35 million patients from 1,574 general practices in England to identify patient groups receiving only antidepressants and statin+antidepressant treatment in the QResearch database.
Discontinuation implied one of the following for a patient: i) over a 30-day gap between the termination and start of antidepressant prescription, considering the average prescription duration of 28-30 days; ii) switching to another antidepressant; or iii) a patient being prescribed an additional antidepressant, mood stabilizer or antipsychotic.
Results The final cohort comprised 673,177 patients, of which 46,482 patients were receiving an antidepressant with statin and 626,335 were antidepressant-only. Lower all-cause discontinuation of antidepressant treatment in the group using antidepressant+statin showed higher acceptability compared to the antidepressant-only group at all time points. These results remained consistent even after adjusting for confounders.
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