Researchers at Children's Hospital of Philadelphia (CHOP), St. Jude Children's Research Hospital (St.
St. Jude Children 's Research Hospital Aug 14 2024 Research ers at Children 's Hospital of Philadelphia , St. Jude Children 's Research Hospital and the Children 's Oncology Group today announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia , an aggressive and high-risk form of cancer, to one frequently driven by genetic changes in non-coding portions of our DNA .
David T. Teachey, MD, attending physician, Director of Clinical Research at the Center for Childhood Cancer Research at CHOP and Chair of the Acute Lymphoblastic Leukemia disease committee in the COG In this case, researchers studied more than 1,300 patients treated on the COG AALL0434 clinical trial and sequenced both the tumor and non-tumor genomes of each patient. While the researchers previously suspected that non-coding DNA in T-ALL played an important role, this study's findings are the first ever to establish that at a large scale.
"It was striking how abundant these non-coding changes were and how many of them were enhancer perturbation events, whether it was hijacking or co-option of an existing enhancer, or changes that generated a new enhancer," said Charles Mullighan, MBBS, MD, St. Jude Children's Research Hospital, Comprehensive Cancer Center deputy director and Department of Pathology member.
Hospital Leukemia Research Acute Lymphoblastic Leukemia Adolescents Cancer Cell Diagnostic DNA Gene Genetic Genome Genomic Oncology Pathology T-Cell Tumor
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