A new study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior.
Eötvös Loránd UniversityAug 14 2024 A new study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior. Chromatin, the compact form of DNA , not only packages genetic material but also plays a crucial role in gene regulation.
"This gene plays a role in neural development and pathways related to anxiety and sociability and is likely a key determinant of the friendly behavior shaped by domestication. In our current study, we aimed to investigate how genetic variants influence the 3D structure of the DNA containing this gene," says vonHoldt, lead author of the publication in BMC Genomics. "The GTF2I gene has several variants, with the ancient, wolf-like variant found in three out of ten individuals.
"Brainstem samples were collected from pet dogs euthanized for medical reasons and donated for research. We included only dogs without major nervous system illnesses," explains Dr. Eniko Kubinyi, head of the Department of Ethology at ELTE, who established the bank with geneticist Dr. Sára Sándor and veterinarian Dr. Kálmán Czeibert andmaintains it with grants from the Hungarian Academy of Sciences.
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