It's one of the basic tenets of biology: We get our DNA from our mom and our dad.
University of Colorado at Boulder Oct 9 2024 It's one of the basic tenets of biology: We get our DNA from our mom and our dad.
The study, conducted in roundworms, offers new clues about what may drive some mitochondrial disorders, which hinder the body's ability to produce energy and collectively impact about one in 5,000 people. It also presents a novel approach for potentially preventing or treating them – a simple vitamin known as Vitamin K2.
When cellular batteries run low Often described as cellular batteries, mitochondria produce adenosine triphosphate , the energy that drives virtually all cell functions.In 2016, Xue published one of the first papers to spell out just how paternal mitochondria gets wiped out – via a multi-faceted, self-destruct mechanism known as "paternal mitochondria elimination ," a process documented in worms, rodents and humans alike.
The team was unable to completely halt PME in the worms – a testament to how resilient this evolutionary process is. But they were able to delay it by about 10 hours. When they did so in fertilized eggs, it led to significant reductions in ATP. If the worms survived at all, they had impaired cognition, altered activity and difficulty reproducing.
DNA Embryo Genome Inherit Mitochondria OCT Reproduction Research Sperm
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