Researchers from the lab of Prof. Sarah-Maria Fendt (VIB-KU Leuven) and colleagues have uncovered that the availability of the amino acid aspartate is one reason why the lung is a frequent organ of metastasis.
Vlaams Instituut voor BiotechnologieJan 1 2025 Research ers from the lab of Prof. Sarah-Maria Fendt and colleagues have uncovered that the availability of the amino acid aspartate is one reason why the lung is a frequent organ of metastasis. Their work appears in Nature and improves our understanding of cancer biology while providing the foundation for new therapeutic interventions in metastatic diseases.
To find out, the team of Prof. Sarah-Maria Fendt and colleagues investigated the gene expression in cells from aggressive lung metastases. They found evidence for an alternative 'translation program.' What does this mean? Translation is the process that uses our genetic code as a blueprint to make proteins in cells. A change in the translational program results in a set of different proteins that allow cancer cells to grow easier in the lung environment.
Starting the translational program Many proteins in our bodies can affect the translation process, among them the so-called initiation factors. One such initiation factor is eIF5A, which kickstarts translation. In the cells of cancer cells within lung metastases, the researchers found an activating modification to eIF5A called 'hypusination', which was associated with higher cancer aggressiveness of lung metastases.
Metastasis Amino Acid Breast Cancer Gene Gene Expression Lungs Protein Receptor Research Translation
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