Researchers developed DNA methylation-based models predicting maximum lifespan, gestation, and sexual maturity across 348 mammalian species, revealing key epigenetic markers of longevity.
By Pooja Toshniwal PahariaJun 10 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Science Advances, researchers estimated the maximal longevity, gestation period, and sexual maturity age using deoxyribonucleic methylation by examining 15,000 samples from 348 mammalian species.
About the study In the present study, researchers created multivariate regressions to estimate maximal longevity and related species-specific features. Researchers created tissue-agnostic life-history predictions based on average methylation levels across all species and tissue types. They tested these predictors on chosen animals with diverse tissue types to better understand how tissue type affects longevity estimates. The researchers used elastic net regression models to estimate the maximal life span based on CpG methylation data and taxonomic order indications.
The DNAm maximal longevity estimator did not detect intra-species variations in longevity, such as among different dog breeds. Maximal longevity is ascertained partially by epigenetic signatures that are intrinsic properties and are distinct from those related to individual-level death risks. Mammalian array-generated DNAm data may precisely classify sample species, sex, and tissue.
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