Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such as the lungs and heart. It is considered a rare disease, and little is yet known about its development and progression.
Systemic sclerosis research finds protein TLR8 influences the production of disease-related cytokines. DOI: 10.1002/art.42964
The scientists then stimulated the receptor by adding various agonists. This sets the signaling chain in motion and leads to the production of cytokines in the cell, which in turn can trigger further steps in the immune response. However, in this series of experiments, neither the TLR8 concentrations nor the amount of cytokines produced differed.
IL-10 stands for interleukin-10. This cytokine has an anti-inflammatory but also profibrotic effect, i.e., it promotes the abnormal growth of connective tissue."IL-10 could contribute to the fibrotic skin changes that are characteristic of systemic sclerosis," says Graalmann.."Unfortunately, however, we cannot yet draw any direct conclusions for treatment because the number of patients is so small," Graalmann states.
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