The causative role of age-associated pre-existing senescent cells on COVID-19 severity NatureAging aging covid COVID19 SARSCov2 senescentcells lungs
By Susha Cheriyedath, M.Sc.Jul 10 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nature Aging Journal, researchers investigated the role of senescent cells in the context of SARS-CoV-2 infection.
Targeting senescent cells with senolytic drugs, such as ABT-263, has shown promise in improving outcomes in various diseases. Histopathological assessments, immunohistochemistry, and immunofluorescence techniques were employed to evaluate lung tissue changes, protein expression, and cellular senescence.
In addition to senescent cells, aged hamsters displayed a higher viral load and more severe lung damage following SARS-CoV-2 infection. This is attributed to the higher expression levels of genes encoding viral proteins and increased angiotensin-converting enzyme 2 receptor expression in the aging lung tissue.
Remarkably, ABT-263 treatment demonstrated several beneficial effects in the context of SARS-CoV-2 infection. It reduced the viral load in the lungs of aged hamsters, potentially due to the depletion of ACE-2-expressing senescent cells. Proteomic analysis indicated that ABT-263 treatment downregulated proteins associated with chronic lung diseases, including those involved in the ubiquitin-proteasome system and cell adhesion molecules.
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