Researchers examine how sleep impacts inflammation and recovery following a heart attack.
By Dr. Chinta SidharthanReviewed by Benedette Cuffari, M.Sc.Oct 31 2024 Study reveals how sleep reduces cardiac inflammation and boosts recovery after heart attack s by regulating immune and neural pathways.
The brain-heart connection The brain and heart are closely connected and interact through immune signaling and neural pathways to maintain health. Sleep is particularly important for cardiovascular health, as poor sleep quality and insufficient sleep can increase the risk of heart attacks. About the study For human studies, the researchers analyzed brain tissues obtained from donors who experienced myocardial infarctions within two weeks before death. Any individuals with a history of neurodegenerative disorders, brain trauma, cancer, or stroke were excluded from the analysis. Human tissue samples were stained for C-C motif chemokine receptor-2 and cluster of differentiation 68 .
A randomized controlled crossover trial was also conducted to investigate how chronic insufficient sleep affects immune cell programming. Trial participants were subjected to adequate and restricted sleep conditions over six weeks, following which blood samples were collected for analysis. Study findings Cardiovascular injuries like myocardial infarction increase slow-wave sleep in mice, which disrupts their natural sleeping patterns, thus suggesting a link between sleep regulation and immune responses after cardiac events.
Flow cytometry analysis also revealed an influx of monocytes into various regions of the brain such as the choroid plexus, third ventricle, and thalamus within 24 hours of a myocardial infarction. These monocytes can release signals that increase slow-wave sleep, which has been shown to support the healing process.
Sleep Blood Blood Vessels Brain Cardiovascular Disease Cell Chemokine Cytometry Flow Cytometry Heart Attack Hypothalamus Inflammation Monocyte Myocardial Infarction Oxygen Research RNA
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