The Hidden Roles of Dopamine and Serotonin: Scientists Solve Monoamine Mystery

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The Hidden Roles of Dopamine and Serotonin: Scientists Solve Monoamine Mystery
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Pictured is an optical section of planarian testes, showing mRNAs expressed at different stages of spermatogenesis, including early spermatogonia and spermatocytes . DNA staining highlights changes in testis cell nuclei throughout spermatogenesis. Melanie Issigonis et al. found that the enzyme AADC in reproductive niche cells helps the enzyme NRPS produce the dipeptide β-alanyl-tryptamine .

Melanie Issigonis, Research Investigator, Morgridge Institute for Research. Credit: Morgridge Institute for Research The opposite occurred in testes, Issigonis says. In normal testes, if you cut them open like a watermelon, the stem cells would be found along the periphery like the rind, but only a small number are made. “When Umair knocked down, the testes were completely filled with germline stem cells,” she says. “No sperm was being made; testes were filled with germ cell tumors, essentially.

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