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A team led by researchers from the Baylor College of Medicine in Texas used brain scans from 12 people with treatment-resistant OCD, who were undergoing"Recent advances in surgical neuromodulation have enabled long-term continuous monitoring of brain activity in OCD patients during their everyday lives,""We used this novel opportunity to identify key neural signatures that can act as predictors of clinical state.".
Tracking low-frequency brain oscillations in the theta to alpha range, the researchers found a specific, regular 24-hour circadian rhythm in ventral striatum neural activity at the 9Hz frequency that was disrupted by the application of DBS treatment. The team thinks this disruption might be a sign of change in the patient's rituals and neurological responses to events that happen through the day.psychiatrist Wayne Goodman, from the Baylor College of Medicine."Thus, we think this loss of a highly predictable neural activity indicates that the participants engaged in fewer repetitive and compulsive OCD behaviors."
Mapping neural patterns and how they change in response to DBS could reveal which patients are responding well to the treatment, which doses are working best, and which patients might have to move on toof the adult US population will experience OCD at some point in their lives, so if improvements in treatment can be found, then we're talking about changes in millions of lives.
"We are excited by the potential possibility that such similar neural activity signatures may underlie other neuropsychiatric disorders and could serve as biomarkers to diagnose, predict, and monitor those conditions,"
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