The prevalence and spectrum of neurological and psychiatric presentations of human monkeypox infection QMUL Cambridge_Uni EdinburghUni KingsCollegeLon monkeypox infection virus disease neurology
By Dr. Sanchari Sinha Dutta, Ph.D.Sep 12 2022Reviewed by Danielle Ellis, B.Sc. The review article has recently been published in eClinicalMedicine.
The most prominent symptom of monkeypox infection is mild-to-severe risk rashes or lesions. Regarding rare symptoms, a few studies have indicated monkeypox-related neuropsychiatric manifestations. Since smallpox and monkey belong to the same viral family and smallpox infection is significantly associated with neurological symptoms, a systematic analysis of monkeypox-related neuropsychiatric manifestations might be relevant.
From an initial screening of 1,705 studies, 19 were included in the final analysis. Most studies were cohort studies and case series with no control groups. A total of 1,512 individuals participated in these studies, with 1031 having a laboratory-confirmed monkeypox infection. Overall, the quality of selected studies was moderate.
In retrospective studies selected for the analysis, case note review was mostly used to evaluate neuropsychiatric symptoms. Similarly, in prospective studies, a combination of clinical interview and questionnaire was used for symptom evaluation. No significant changes in prevalence were observed by excluding the studies that are different from the majority in terms of study design, inclusion criteria, data collection, symptom diagnosis, and temporality of symptoms.
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