This 19th-Century killer is making a comeback – and with protection from the whooping cough vaccine waning over time, the hunt is on for something longer-lasting.
Whooping cough wasn't really on Juliet Lautenbach's radar. During her pregnancy and her daughter's childhood, both had received free public vaccines against whooping cough along with all the other standard immunisations.
Thankfully Lautenbach's daughter survived that bout of whooping cough, as well as a later one as a teenager. The vaccine may well have. But it wasn't perfect, Lautenbach says she "didn’t realise until much later that the whooping cough one actually became less and less effective" over time.. Pertussis, which typically resurges cyclically, is currently on the rise in many countries, after a quiet period during the Covid-19 pandemic.
Daniela Hozbor, a bacterial vaccine researcher at the Institute of Biology and Molecular Biology at La Plata National University, Argentina , explains just how easily pertussis spreads: if there's one infected person in a room, within an hour roughly 90% of susceptible people there may contract the disease. That's why it's so important to prevent pertussis with vaccination rather than simply relying on antibiotics afterward, which won't stop the contagion, Hozbor says.
In Argentina, a mother or a healthcare worker might need seven or more pertussis vaccine doses in a lifetime Importantly, the BPZE1 vaccine looks likely to be much longer-lasting than existing vaccines. It induces immunity markers not just in the blood, like acellular vaccines, but also in the. This location is important. Kingston Mills, a professor of experimental immunology at Trinity College Dublin, believes that "what's clear from all the preclinical work is that nasally delivered vaccines are going to be the vaccines of the future for pertussis".
, as BPZE1 would be, rather than through injection, as the existing pertussis vaccines are. But this won't fully solve the issue of. Hozbor stresses that more vaccine confidence is required overall, noting that since pertussis is so contagious, high vaccination of the population is needed to prevent outbreaks – ideally at least 90% or 95%.. Locht hopes that the BPZE1 vaccine will be cheaper to make than the existing options.
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