The safety and tolerability of Remdesivir in children affected by COVID-19 researchsquare unito UniPadova COVID19 coronavirus covid children pediatrics
By Neha MathurFeb 2 2023Reviewed by Danielle Ellis, B.Sc. In a recent study posted to Research Square* and under review at the European Journal of Pediatrics, researchers reported findings of a multicenter study conducted across ten hospitals in Italy to investigate the safety of Remdesivir in children affected by coronavirus disease 2019 . Additionally, they examined its tolerability and the clinical characteristics of RDV-treated pediatric patients post-treatment.
The team administered RDV based on the children's weight. For instance, children weighing less than 40 kg received five and 2.5 mg/kg RDV on day 1 and from day 2 onwards, respectively. They increased RDV dosage for children weighing over 40 kg. They monitored liver enzymes every two to three days in all drug recipients and checked their renal function during and after RDV treatment.
Study findings Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy With a cohort of 50 children, of which 32 were boys, the study presents findings from the second-largest dataset on the use of RDV for pediatric COVID-19 treatment. Only one was a neonate, and the remaining were young children with an average age of 12.8 years.
In a nutshell, the study cohort well-tolerated RDV. Intriguingly, RDV was administered in many children diagnosed with severe pneumonia before they needed supplemental oxygen. Yet, it had a few side effects. Thus, pneumonia onset could be considered an important criterion for RDV use in children. Due to bradycardia in three children, RDV treatment had to be discontinued, which restored the heart rate to normal within 24 hours.
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