The Intensive Therapy Units (ITU) at the county’s two acute hospitals are receiving visits from therapy dogs to help boost health and wellbeing.
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Epigenetic state determines the in vivo efficacy of STING agonist therapy - Nature CommunicationsSTING agonists have shown limited efficacy in early-phase clinical trials despite promising pre-clinical data. This study shows the potential clinical relevance of the use of combination STING agonists and demethylating agent therapies to induce the expression of STING.
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12 brilliant books about mental health and wellbeing (that are actually helpful)Whether you’re interested in learning more about mental health, are looking for advice or simply want to feel less alone, these brilliant books, essays and memoirs are a good place to start.
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Derbyshire crash firefighter has life-changing injuriesIn a statement, her family - who have requested she not be named - said she was out of intensive care.
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More than 1,000 sign petition to support Belfast mum in need of lung transplantMore than 1,000 people have signed a petition in support of a North Belfast mum who is in desperate need of a lung transplant
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Former Woolworths in Northampton to become shops and flatsThe scheme proposes three retail units on the ground floor and a mix of studio and flats in the upper floors.
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Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis - Critical CareBackground Current practice guidelines for optimal infusion rates during early intravenous hydration in patients with acute pancreatitis (AP) remain inconsistent. This systematic review and meta-analysis aimed to compare treatment outcomes between aggressive and non-aggressive intravenous hydration in severe and non-severe AP. Methods This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We systematically searched PubMed, Embase and Cochrane Library for randomized controlled trials (RCTs) on November 23, 2022, and hand-searched the reference lists of included RCTs, relevant review articles and clinical guidelines. We included RCTs that compared clinical outcomes from aggressive and non-aggressive intravenous hydration in AP. Meta-analysis was performed using a random-effects model for participants with severe AP and non-severe AP. Our primary outcome was all-cause mortality, and several secondary outcomes included fluid-related complications, clinical improvement and APACHE II scores within 48 h. Results We included a total of 9 RCTs with 953 participants. The meta-analysis indicated that, compared to non-aggressive intravenous hydration, aggressive intravenous hydration significantly increased mortality risk in severe AP (pooled RR: 2.45, 95% CI: 1.37, 4.40), while the result in non-severe AP was inconclusive (pooled RR: 2.26, 95% CI: 0.54, 9.44). However, aggressive intravenous hydration significantly increased fluid-related complication risk in both severe (pooled RR: 2.22, 95% CI 1.36, 3.63) and non-severe AP (pooled RR: 3.25, 95% CI: 1.53, 6.93). The meta-analysis indicated worse APACHE II scores (pooled mean difference: 3.31, 95% CI: 1.79, 4.84) in severe AP, and no increased likelihood of clinical improvement (pooled RR:1.20, 95% CI: 0.63, 2.29) in non-severe AP. Sensitivity analyses including only RCTs with goal-directed fluid therapy after initial fluid resuscitation therapy yielded consistent results. Conclu
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