Tirzepatide, a new injectable weight-loss drug with the trade name Zepbound, reduced the risk of diabetes in patients with obesity and prediabetes by more than 90% over a three-year period, compared with placebo, according to the results of a new study led by investigators at Weill Cornell Medicine, NewYork-Presbyterian, Yale School of Medicine...
Weill Cornell Medicine Nov 26 2024 Tirzepatide, a new injectable weight-loss drug with the trade name Zepbound, reduced the risk of diabetes in patients with obesity and prediabetes by more than 90% over a three-year period, compared with placebo, according to the results of a new study led by investigators at Weill Cornell Medicine , NewYork-Presbyterian, Yale School of Medicine and other institutions.
"These results show that type 2 diabetes may be prevented, even in people who are on the verge of it, by using a medicine that causes weight loss," said study co-author Dr. Louis Aronne, the Sanford I. Weill Professor of Metabolic Research and director of the Comprehensive Weight Control Center, which is part of the Division of Endocrinology, Diabetes, and Metabolism at Weill Cornell Medicine.
Tirzepatide belongs to a broad new class of drugs that simulate nutrient-stimulated hormones, helping patients lose significant weight and improve their blood sugar control. The drugs work, at least in part, by activating one or multiple receptors throughout the body, including glucagon-like peptide 1 and glucose-dependent insulinotropic peptide receptors on cells in the brain, pancreas and elsewhere.
The study found that after 176 weeks, only 10 tirzepatide-treated patients progressed to diabetes, representing a roughly 93% reduction in risk compared to the placebo group. More than 90% of the patients on tirzepatide had normal A1c levels at 176 weeks, versus 59% of placebo-treated patients.
Blood Blood Sugar Drugs GLP-1 Glucose Medicine Obesity Placebo Prediabetes Type 2 Diabetes Weight Loss
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