Early life exposure to a class of endocrine-disrupting chemicals (EDCs) called polychlorinated biphenyls (PCBs) may lead to behavioral problems in rats, according to a new animal study published in the Journal of the Endocrine Society.
The Endocrine SocietyDec 10 2024 Early life exposure to a class of endocrine-disrupting chemicals called polychlorinated biphenyls may lead to behavioral problems in rats, according to a new animal study published in the Journal of the Endocrine Society.
PCBs have been banned for decades but are still persistent in the environment. PCBs are found in contaminated soil, sediment and certain types of fish due to environmental contamination. They have been linked to reproductive and anxiety disorders. We found rats exposed to PCBs during the perinatal period may have developmental and hormonal changes. Our study emphasizes and supports previous research on how PCB exposure can affect neurobehavioral outcomes." The researchers fed a human-relevant PCB mixture or the placebo to about 40 pregnant rats and found the EDCs can reprogram their pups' developing neuroendocrine system and lead to neurobehavioral problems in early life.
Cancer Endocrine Hormone Obesity Research
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