Zizyphi spinosi semen demonstrates neuroprotective effects, improving cognitive function and reducing amyloid and tau pathology in models of aging and dementia.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMNov 8 2024 Study finds Zizyphi spinosi semen may reduce brain aging and improve cognitive function in neurodegenerative disease models.
This process leads to cognitive decline and motor impairment, often beginning decades before clinical symptoms appear. Cellular senescence, driven by factors like oxidative stress and telomere attrition, contributes to neurodegeneration by inducing a damaging inflammatory response. Component analysis for jujuboside A, jujuboside B, and spinosin in the ZSS preparations was conducted by Japan Food Research Laboratories. The dried ZSS materials underwent methanol extraction and were analyzed using high-performance liquid chromatography coupled with mass spectrometry.
Study results The effects of ZSS hot water extract on cognitive function and Aβ pathology were assessed in APP23 mice, which model AD. These mice, aged 13-15 months, display Aβ oligomer accumulation and memory impairment. The extract was administered orally at a dosage of 0.1 mg per shot for one month.
Administered at 0.1 and 0.5 mg per shot for one month, the higher dosage resulted in complete recovery of cognitive function to levels like non-transgenic littermates, while the lower dose produced moderate effects. The treatment effectively reduced phosphorylated tau levels and tau oligomers in the hippocampus and cerebral cortex, with significant recovery of synaptophysin levels.
The positive cognitive effects observed in aged mice following treatment with the simple crush powder of ZSS suggested potential brain-rejuvenating properties.
Alzheimer's Disease Assay Brain Cognitive Function Cortex Cyclin-Dependent Kinase Dementia DNA Frontotemporal Dementia Hippocampus Immunotherapy Kinase Kinase Inhibitor Neurodegeneration Neurodegenerative Disease Neurodegenerative Diseases Neurogenesis Oxidative Stress Parkinson's Disease Pathology Research Semen Stress Telomere Transgenic
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