The first randomized, placebo-controlled clinical trial evaluating the impact of therapeutic monoclonal antibodies on the risk of developing long COVID was led by researchers at Weill Cornell Medicine.
Weill Cornell Medicine Oct 17 2024 The study, published Sept. 1 in eClinical Medicine , details an international, multicenter phase 2/3 clinical trial that found a combination of amubarvimab and romlusevimab did not reduce the occurrence of long COVID symptoms.
The study, led by Dr. Teresa Evering, assistant professor of medicine in the division of infectious diseases at Weill Cornell Medicine and an infectious disease physician at NewYork-Presbyterian/Weill Cornell Medical Center, evaluated how antibody treatment, given during acute infection, impacted after-recovery outcomes at nine months.
Previously, Dr. Evering and colleagues showed that those treated in the trial with the antibodies amubarvimab and romlusevimab during acute infection were 79 percent less likely to be hospitalized or die of COVID within four weeks than those who had received a placebo. Future research should focus on identifying the mechanisms underlying long COVID, especially in relation to how different therapeutic agents for acute COVID-19 may influence longer term outcomes. Additional large-scale randomized, placebo-controlled studies are needed to assess the efficacy of early interventions in reducing long COVID prevalence."
Antibodies Antibody Clinical Trial Covid-19 Efficacy Fatigue Infectious Diseases Medicine Research SARS SARS-Cov-2
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