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At the halfway point of the study, people taking the highest dose of retatrutide lost an average of 17.5 percent of their body weight. After 48 weeks, patients on the 12-mg dose lost a whopping 24.2 percent of their body weight. Even more staggering, a quarter of these participants lost 30 percent or more of their baseline body weight. For comparison, those who took a placebo only lost 1.6 percent of their body weight at 24 weeks and 2.1 percent at 48 weeks.
Adverse events with retatrutide were similar to those seen with existing weight-loss drugs. Patients reported gastrointestinal issues, namely nausea, diarrhea, and vomiting, which were mild to moderate in severity. These mainly occurred during dose escalation, when patients gradually increased the amount of retatrutide they were injecting each week to improve tolerability.
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