Researchers at Karolinska Institutet and the University of Gothenburg have identified two types of metabolic-associated fatty liver disease - a liver-specific type and a systemic type that affects other organs and tissues.
Karolinska InstitutetDec 10 2024 The discovery could lead to improved diagnosis and treatment of this growing patient group. Two studies are published back-to-back in Nature Medicine .
Comprehensive analyses Researchers at Karolinska Institutet and the University of Gothenburg in Sweden have now identified two different types of MASLD by analyzing data from over 36,000 participants from the UK Biobank and from other studies. Predicting disease progression The researchers used genetic tests to identify 27 new genetic variants linked to MASLD. By analysing these genes, they were able to determine two different risk scores related to the two types of MASLD. The liver-specific type is more aggressive and can lead to severe liver damage but protects against cardiovascular disease, while the systemic type is associated with a higher risk of diabetes, cardiovascular disease, heart and kidney failure.
"This work on clustering using simple clinical variables is of utmost importance because it allows us to differentiate at an individual level who has MASLD and will develop cardiovascular disease and who will not," says Stefano Romeo.Advances in precision medicine The study also highlights the importance of genetic research in understanding complex diseases like MASLD and the mechanisms causing the cardio-renal-metabolic syndrome.
Liver Liver Disease Research Cancer Cardiovascular Disease Cirrhosis Genetic Heart Liver Cancer Medicine Metabolic Syndrome Obesity Precision Medicine Syndrome
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