Two new studies from UC San Francisco are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and insomnia at night.
University of California - San FranciscoAug 19 2024 Two new studies from UC San Francisco are pointing the way toward round-the-clock personalized care for people with Parkinson's disease through an implanted device that can treat movement problems during the day and insomnia at night.
For the first study, researchers conducted a clinical trial with four people to test how well the approach worked during the day, comparing it to an earlier brain implant DBS technology known as constant or cDBS. "There's been a great deal of interest in improving DBS therapy by making it adaptive and self-regulating, but it's only been recently that the right tools and methods have been available to allow people to use this long-term in their homes," said Starr, who was recruited by UCSF in 1998 to start its DBS program.
Related StoriesTreatment usually begins with levodopa, a drug that replaces the dopamine these cells are no longer able to make. However, excess dopamine in the brain as the drug takes effect can cause uncontrolled movements, called dyskinesia. As the medication wears off, tremor and stiffness set in again.
So, he found alternative signals in a different region of the brain, called the motor cortex, that wouldn't be weakened by the DBS stimulation. John Ngai, PhD, who directs the Brain Research Through Advancing Innovative Neurotechnologies® initiative at the National Institutes of Health, said the study promises a marked improvement over current Parkinson's treatment.
Brain Implant Brain Stimulation Clinical Trial Deep Brain Stimulation Dopamine Insomnia Medicine Neurology Neuromodulation Parkinson's Disease Research Sleep Technology
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