University of Illinois Chicago scientists have redesigned a treatment for the most common pediatric leukemia to eliminate its severe side effects, like blood clots and liver damage.
University of Illinois ChicagoJan 31 2025 University of Illinois Chicago scientists have redesigned a treatment for the most common pediatric leukemia to eliminate its severe side effects, like blood clots and liver damage. If approved, the new drug may be tolerated by a broader range of leukemia patients and even be used to treat other cancers.
I am excited for the opportunity to translate my academic research into a potential treatment that addresses an unmet need. The reality is that the pharmaceutical industry is primarily interested in de-risked molecules, and our goal is to de-risk our novel asparaginase sufficiently so that it becomes an interesting therapeutic for a company."
To solve these issues, Lavie and his research group went back to the animal where asparaginase was originally discovered in the 1950s: the guinea pig. Because the enzymes in mammals are similar to those in humans, the researchers hoped that the guinea pig enzymes would not provoke an immune response in patients.
In making the changes, they serendipitously extended the half-life of the enzyme, which would mean less frequent treatments when used against cancer and reducing the burden on patients receiving the treatment.
Acute Lymphoblastic Leukemia Asparaginase Asparagine Blood Blood Cancer Children Compound Enzyme Immune Response Laboratory Leukemia Liver Liver Cancer Melanoma Protein Protein Engineering Research Therapeutics Tumor
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