When most people think of dementia, including Alzheimer's disease, they probably think of memory loss first.
Michigan Medicine - University of MichiganOct 7 2024 When most people think of dementia, including Alzheimer's disease, they probably think of memory loss first.
Using two types of advanced medical imaging to study the brains of 128 people in the early stages of dementia, they show links between one of the brain's most crucial communication networks, a protein called tau, and the level of behavioral symptoms a person has. While the one-time imaging of these 128 research volunteers can't show cause and effect, the strong association between tau, salience network disruption and behavior change is intriguing, the team says.
The researchers, from the Research Program on Cognition and Neuromodulation Based Interventions , are led by Alexandru D. Iordan, Ph.D. and program leader Benjamin M. Hampstead, Ph.D. Both are faculty in the U-M Medical School's Department of Psychiatry. Related StoriesThe salience network was the only one of the three networks whose level of integrity correlated with the presence of tau and the severity of dementia-related behavioral issues. The default-mode network appears to be involved as a supporting player. The third network studied, called the frontoparietal network, was not related to behavioral symptoms.
Dementia Aging Alzheimer's Disease Biomarker Brain Stimulation Imaging Medical Imaging Medicine Nerve Neuromodulation Pathology Ph Protein Research
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