TLS are accumulations of lymphoid cells that share similar cellular compartments, organization, and function as secondary lymphoid organs. Importantly, the presence of these structures in inflamed salivary glands associated with active disease, increased autoantibody production, and malignancy risk.
European Alliance of Associations for Rheumatology Jun 16 2024
To address this, the team mapped both identified cell types and novel populations, clustering tissue architectural features to define eight so-called neighborhoods. Some of these were enriched with epithelial cells, but others were associated with different immune cell populations. One neighborhood was enriched with IgA plasma cells, and was associated with myeloid populations – in contrast to other IgG plasma cells niches.
Organoids Research Rheumatology Salivary Gland
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