There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine.
ElsevierAug 23 2024 The findings, detailed in an article in The American Journal of Pathology , published by Elsevier, can help advance the development of novel, targeted, naturally occurring probiotic therapy for patients with inflammatory bowel disease and other inflammatory diseases, such as fatty liver disease or alcoholic liver disease , that are associated with a leaky or disordered intestinal barrier.
Patients with active IBD have elevated proinflammatory cytokines, including tumor necrosis factor -α and IL1β. TNF-α levels are markedly elevated in intestinal tissue, serum, and stool of patients with IBD and at elevated levels produce an increase in intestinal tight junction permeability. TNF-α plays a central role in promoting intestinal inflammation in patients with IBD, and anti–TNF-α antibodies are highly effective in the treatment of the active disease.
Bacteria Gene Inflammation Kinase Liver Liver Disease Medicine Necrosis Pathology Probiotic Promoter Promoter Region Protein Protein Synthesis Receptor Research Retinoid Signaling Pathway Transcription Tumor Tumor Necrosis Factor Ulcerative Colitis
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Probiotic offers protection against intestinal damageThere is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine.
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A potential pathway may guide new therapies for inflammatory bowel disease and other inflammatory diseasesThere is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium bifidum BB1, enhances intestinal barrier function and protects against penetration of bacteria and various harmful agents in the intestine.
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